Opus LAP
Opus LAP project (National Science Center) titled “Engineering Biocompatible and Bioactive Stents for Improved Endothelial Integration in Cardiovascular Applications” (Contract number: 2024/55/I/ST5/02185).
This project aims to develop next-generation bioactive, slowly degradable stents for applications in cardiovascular disease. By combining naturally derived and synthetic polymers, the stents will feature improved mechanical stability, biocompatibility, and the ability to support the growth of a functional endothelial cell layer. A bioactive surface will be incorporated to enhance the interaction between the stent and surrounding tissue, improving long-term performance.
The work will involve advanced material synthesis, characterization, drug release studies, antibacterial assays, and biological evaluation under in vitro, ex vivo, and in vivo conditions using a porcine model. The project will also utilize volumetric bioprinting to deposit functional layers inside the stent lumen, as well as computational simulations and perfusion bioreactor systems to optimize design and performance. The final goal is to deliver a prototype of a 3D-printed or casted bioactive stent with proven tissue compatibility and mechanical stability, paving the way for improved cardiovascular implants.
The Opus project includes international collaboration with the Institute of the Czech Academy of Sciences, providing access to complementary expertise and facilities.
The OPUS LAP grant will be carried out at the Center for Advanced Technologies of Adam Mickiewicz University in Poznań between 2026 and 2029. Job offers for a postdoctoral researcher and PhD students will be announced soon. Individuals interested in joining the project are welcome to contact the Head of the Laboratory via email.
Team Members:
Principal Investigator
Ph.D in Biological Sciences, Faculty of Biology, Adam Mickiewicz University in Poznan, Poland
Current affiliation:
Center for Advanced Technologies at Adam Mickiewicz University in Poznan, Poland
Postdocs:
We are looking for passionate postgraduates who share our excitement for either cell biology or 3D bioprinting, materials engineering, or stem cell biology. Postdocs will also have the opportunity to start their own research projects or lead ongoing ones. These positions are fully funded. To apply, please send a two-paragraph cover letter outlining your scientific goals and why you’d like to join our team, along with your CV and three references to jagoda.litowczenko@amu.edu.pl.
PhD Students: